Premium
Chemistry of Phosphonium Ylides. Part 39: Facile Synthesis of Aziridine, Pyridine, Pyrolotriazole Chromenones and Azaphosphinin Chromenones as Antitumor Agents
Author(s) -
AbdElMaksoud Mansoura A.,
Maigali Soher S.,
Soliman Fouad M.
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2205
Subject(s) - phosphonium , chemistry , aziridine , ylide , allylic rearrangement , pyridine , nucleophile , triphenylphosphine , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , ring (chemistry)
The reaction of 4‐azido‐2‐oxo‐2 H ‐chromene‐3‐carbaldehyde with the active nucleophilic phosphacumulenes yielded the corresponding phosphanylidene‐aziridines and chromeno‐pyrolo‐triazoles. On the other hand, the reaction of the allylic phosphonium ylide, hexaphenylcarbodiphosphorane with the azido compound, was also undertaken. In this case, the phosphanylidene‐chromeno‐triazinone was obtained. Further assessment of these new compounds against (breast: MCF‐7 and liver: HPEG2) human solid tumor cell lines is necessary.