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Synthesis, Characterization, and DGAT1 Inhibition of New 5‐Piperazinethiazole and 5‐Piperidinethiazole Analogs
Author(s) -
Kadam Kishorkumar S.,
Gandhi Thirumanavelan,
Reddy M. Maheshkumar,
Gupte Amol,
Sharma Rajiv
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2194
Subject(s) - chemistry , diacylglycerol kinase , nuclear magnetic resonance spectroscopy , enzyme , in vitro , biosynthesis , triglyceride , characterization (materials science) , stereochemistry , organic chemistry , biochemistry , cholesterol , nanotechnology , materials science , protein kinase c
In this study, a novel series of 5‐piperazinethiazole 2,2‐dimethylbutanoic acid and 5‐piperidinethiazole 2,2‐dimethylbutanoic acid derivatives have been synthesized. Structures of the newly synthesized compounds have been elucidated using 1 H‐NMR, 13 C‐NMR, high‐resolution mass spectroscopy, and high‐performance liquid chromatographic analysis. The synthesized derivatives have been evaluated in vitro for their ability to inhibit the enzyme diacylglycerol acyltransferase 1 responsible for triglyceride biosynthesis.