Synthesis, Characterization, and DGAT1 Inhibition of New 5‐Piperazinethiazole and 5‐Piperidinethiazole Analogs | Zendy

Kadam Kishorkumar S. | Zendy; Gandhi Thirumanavelan | Zendy; Reddy M. Maheshkumar | Zendy; Gupte Amol | Zendy; Sharma Rajiv | Zendy

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Synthesis, Characterization, and DGAT1 Inhibition of New 5‐Piperazinethiazole and 5‐Piperidinethiazole Analogs

Author(s) -

Kadam Kishorkumar S.,

Gandhi Thirumanavelan,

Reddy M. Maheshkumar,

Gupte Amol,

Sharma Rajiv

Publication year - 2015

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2194

Subject(s) - chemistry , diacylglycerol kinase , nuclear magnetic resonance spectroscopy , enzyme , in vitro , biosynthesis , triglyceride , characterization (materials science) , stereochemistry , organic chemistry , biochemistry , cholesterol , nanotechnology , materials science , protein kinase c

In this study, a novel series of 5‐piperazinethiazole 2,2‐dimethylbutanoic acid and 5‐piperidinethiazole 2,2‐dimethylbutanoic acid derivatives have been synthesized. Structures of the newly synthesized compounds have been elucidated using 1 H‐NMR, 13 C‐NMR, high‐resolution mass spectroscopy, and high‐performance liquid chromatographic analysis. The synthesized derivatives have been evaluated in vitro for their ability to inhibit the enzyme diacylglycerol acyltransferase 1 responsible for triglyceride biosynthesis.

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