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Convenient synthesis of substituted 2‐(2‐iminocoumarin‐3‐yl)thieno[2,3‐ d ]pyrimidin‐4‐ones
Author(s) -
Shynkarenko Pavlo E.,
Vlasov Sergiy V.,
Kovalenko Sergiy M.,
Shishkina Svitlana V.,
Shishkin Oleg V.,
Chernykh Valentin P.
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.219
Subject(s) - chemistry , knoevenagel condensation , condensation , simplicity , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , thermodynamics , philosophy , physics , epistemology
The interaction of both 2‐iminocoumarin‐3‐carbonitriles and 2‐iminocoumarin‐3‐carbothioamides with 2‐aminothiophen‐3‐carboxamides lead to formation of 3‐(4‐oxo‐3,4‐dihydrothieno[2,3‐ d ]pyrimidin‐2‐yl)‐2‐iminocoumarins in two steps. The simplicity of the procedure, as well as the high yields of the target products make this method to be a good alternative of Knoevenagel condensation for the synthesis of 3‐(4‐oxo‐3,4‐dihydrothieno[2,3‐ d ]pyrimidin‐2‐yl)‐2‐iminocoumarins. J. Heterocyclic Chem., (2010).
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