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Synthesis of Novel Drug‐Like Small Molecules Based on Quinoxaline Containing Amino Substitution at C‐2
Author(s) -
Rao K. Raghavendra,
Raghunadh Akula,
Mekala Ramamohan,
Meruva Suresh Babu,
Ganesh K. Ravi,
Krishna T.,
Kalita Dipak,
Laxminarayana Eppakayala,
Pal Manojit
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2177
Subject(s) - quinoxaline , chemistry , molecule , substitution (logic) , combinatorial chemistry , drug , small molecule , substitution reaction , organic chemistry , stereochemistry , biochemistry , psychology , psychiatry , computer science , programming language
A series of novel “drug‐like” small molecules based on quinoxaline containing amino substitution at C‐2 were synthesized. All these molecules were prepared either via the reaction of 2‐phenyl‐3‐(piperazin‐1‐yl)quinoxaline with acyl bromides or benzyl bromides or various carboxylic acids or via the reaction of 2‐chloro‐3‐phenylquinoxaline with various amines. The structures of these novel compounds were confirmed by spectral analysis. The strategy used is simple and efficient and afforded good yields of quinoxaline derivatives.