An Efficient Synthesis of Novel 2‐(5‐indolyl)‐1 H ‐benzimidazole Derivatives and Evaluation of Their Antimicrobial Activities

In this paper, we report the synthesis of novel 2‐(5‐indolyl)‐1 H ‐benzimidazole derivatives. The methodology involves the Sonogashira reaction of 4‐(1 H ‐benzimidazol‐2‐yl)‐2‐bromo‐ N,N ‐dimethylaniline ( 3 ) with variety of terminal alkynes to get corresponding novel 4‐(1 H ‐benzimidazol‐2‐yl)‐2‐alkynyl‐ N , N ‐dimethylaniline derivatives ( 4 ). These compounds on iodocyclization afforded novel iodoindolylbenzimidazole derivatives ( 5 ). The resulting compounds were functionalized further via palladium‐mediated carbon–carbon bond formation for generating novel structurally diversified heterocyclic compounds. All these newly synthesized compounds were evaluated for antimicrobial activity .