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An Efficient Synthesis of Novel 2‐(5‐indolyl)‐1 H ‐benzimidazole Derivatives and Evaluation of Their Antimicrobial Activities
Author(s) -
Soodamani Venugopal,
Patel Divyesh,
Nayakanti Devanna,
Josyula Ramanatham
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2174
Subject(s) - chemistry , benzimidazole , antimicrobial , sonogashira coupling , combinatorial chemistry , dimethylaniline , triple bond , palladium , organic chemistry , catalysis , double bond
In this paper, we report the synthesis of novel 2‐(5‐indolyl)‐1 H ‐benzimidazole derivatives. The methodology involves the Sonogashira reaction of 4‐(1 H ‐benzimidazol‐2‐yl)‐2‐bromo‐ N,N ‐dimethylaniline ( 3 ) with variety of terminal alkynes to get corresponding novel 4‐(1 H ‐benzimidazol‐2‐yl)‐2‐alkynyl‐ N , N ‐dimethylaniline derivatives ( 4 ). These compounds on iodocyclization afforded novel iodoindolylbenzimidazole derivatives ( 5 ). The resulting compounds were functionalized further via palladium‐mediated carbon–carbon bond formation for generating novel structurally diversified heterocyclic compounds. All these newly synthesized compounds were evaluated for antimicrobial activity .