Synthesis of Optically Active 2‐Amino‐1,3,4‐oxadiazoles and their Hybrid Peptides | Zendy

Madhu Chilakapati | Zendy; Prabhu Girish | Zendy; Pal Rumpa | Zendy; Guru Row T. N. | Zendy; Sureshbabu Vommina V. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis of Optically Active 2‐Amino‐1,3,4‐oxadiazoles and their Hybrid Peptides

Author(s) -

Madhu Chilakapati,

Prabhu Girish,

Pal Rumpa,

Guru Row T. N.,

Sureshbabu Vommina V.

Publication year - 2015

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2166

Subject(s) - chemistry , peptidomimetic , racemization , amino acid , peptide , oxadiazole , optically active , stereochemistry , combinatorial chemistry , peptide bond , sonication , peptide synthesis , organic chemistry , biochemistry , chromatography

Synthesis of 2-amino-1,3,4-oxadiazole derivatives of N-Cbz(benzyloxycarbonyl)/Boc-protected amino/peptide acids under sonication is described. The conditions involved in the present protocol are simple, mild, and racemization free. The utility of 2-amino group in the substituted oxadiazoles for the incorporation of peptide and ureido bonds to obtain hybrid peptidomimetics is also delineated. The 2-amino-1,3,4-oxadiazole 3b was obtained as a single crystal, and its molecular structure has been confirmed through X-ray crystallographic study

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research