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One‐pot Synthesis of Novel 2,8‐dithioxopyrano[2,3‐d:6,5‐d′]dipyrimidine‐4,6(1 H )‐dione Catalyzed by p ‐Toluenesulfonic Acid
Author(s) -
Mahmoodi N. O.,
Sharifzadeh B.,
Mamaghani M.,
Tabatabaeian K.,
Shoja S.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2165
Subject(s) - chemistry , p toluenesulfonic acid , catalysis , regioselectivity , thiobarbituric acid , organic chemistry , elemental analysis , proton nmr , combinatorial chemistry , medicinal chemistry , enzyme , lipid peroxidation
Novel 2,8‐dithioxopyrano[2,3‐d:6,5‐d′]dipyrimidine‐4,6(1 H )‐dione derivatives were synthesized by a clean and efficient methodologies involving one‐pot regioselective and chemoselective reactions between two moles substituted thiobarbituric acid and 1 mol various aromatic aldehydes in the presence of p ‐toluenesulfonic acid as a catalyst in EtOH with good yields in compression with alternative conditions such as microwave and promoted ultrasound. All of the compounds have been characterized by IR, 1 H NMR, 13 C NMR spectral data, and elemental analyses.