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Cu(I)‐Catalyzed Efficient Synthesis of 2′‐Triazolo‐nucleoside Conjugates
Author(s) -
Mathur D.,
Ra.,
Olsen C. E.,
Parmar V. S.,
Prasad A. K.
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2159
Subject(s) - chemistry , nucleoside , propargyl , conjugate , deoxyuridine , catalysis , carbon 13 nmr , aryl , nucleic acid , stereochemistry , combinatorial chemistry , organic chemistry , dna , biochemistry , mathematical analysis , alkyl , mathematics
A small library of thirty‐two 2′‐triazolyl uridine and 2′‐triazolyl‐5‐methyluridine has been synthesized by Cu(I)‐catalyzed condensation of 2′‐azido‐2′‐deoxyuridine and 2′‐azido‐2′‐deoxy‐5‐methyluridine with different alkynes and aryl propargyl ethers in almost quantitative yields. Triazolo‐nucleoside conjugates, which can be evaluated for different biological activity for suitable drug development, were unambiguously identified on the basis of 1 H NMR, 13 C NMR, IR, and HRMS data analysis. These compounds have been synthesized for the first time and have not been reported in the literature earlier.