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Three‐component synthesis of 4‐aryl‐1 H ‐pyrimido[1,2‐ a ]benzimidazole derivatives in ionic liquid
Author(s) -
Yao Changsheng,
Lei Song,
Wang Cuihua,
Li Tuanjie,
Yu Chenxia,
Wang Xiangshan,
Tu Shujiang
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.215
Subject(s) - chemistry , benzimidazole , ionic liquid , aldehyde , aryl , amine gas treating , combinatorial chemistry , green chemistry , organic chemistry , medicinal chemistry , catalysis , alkyl
A green and simple synthesis of 4‐ayrl‐3,4‐dihydro‐1 H ‐pyrimido[1,2‐ a ]benzimidazole derivatives was accomplished in excellent yields via the reaction of aryl aldehyde, 1,3‐dicarbonyl compounds and 1 H ‐benzo[ d ]imidazol‐2‐amine in ionic liquid of [bmim + ][BF 4 − ]. This protocol has the advantages of easier work‐up, mild reaction conditions, high yields, and an environmentally benign procedure compared with the reported methods. J. Heterocyclic Chem., (2010).