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Synthesis of 4,5,6,7‐Tetrabromo‐1 H ‐benzimidazole Derivatives
Author(s) -
ŁukowskaChojnacka Edyta,
Bretner Maria
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2145
Subject(s) - benzimidazole , chemistry , morpholine , piperazine , benzylamine , aniline , alkylation , organic chemistry , medicinal chemistry , catalysis
A convenient and simple method for the preparation of polybrominated benzimidazole derivatives has been described. Reaction of 4,5,6,7‐tetrabromo‐1‐(3‐chloropropyl)‐1 H ‐benzimidazole, obtained by alkylation of 4,5,6,7‐tetrabromo‐1 H ‐benzimidazole (TBBi) with 1‐bromo‐3‐chloropropane in the presence of KOH, with morpholine, aniline, benzylamine, N ‐methyl piperazine, and 2‐arylpyrrolidines afforded new TBBi derivatives.