Efficient Synthesis of Novel Thiazol‐2‐ylidene‐amides Using Carbonylthiourea  Building Blocks | Zendy

Saeedi Mina | Zendy; Goli Fereshteh | Zendy; Mahdavi Mohammad | Zendy; Asadipour Ali | Zendy; Shafiee Abbas | Zendy; Foroumadi Alireza | Zendy

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Efficient Synthesis of Novel Thiazol‐2‐ylidene‐amides Using Carbonylthiourea Building Blocks

Author(s) -

Saeedi Mina,

Goli Fereshteh,

Mahdavi Mohammad,

Asadipour Ali,

Shafiee Abbas,

Foroumadi Alireza

Publication year - 2015

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2144

Subject(s) - chemistry , dabco , amide , alkylation , propargyl bromide , propargyl , organic chemistry , ethanol , thiazole , combinatorial chemistry , halide , octane , catalysis

In this work, an efficient and versatile synthesis of novel thiazol‐2‐ylidene‐amides from various carbonylthiourea derivatives is described. A sequential alkylation–cyclization reaction between thioureas and propargyl bromide in the presence of DABCO in refluxing ethanol afforded 4‐methylthiazol‐2(3 H )‐ylidene‐amide derivatives in good yields.

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