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Efficient Synthesis of Novel Thiazol‐2‐ylidene‐amides Using Carbonylthiourea Building Blocks
Author(s) -
Saeedi Mina,
Goli Fereshteh,
Mahdavi Mohammad,
Asadipour Ali,
Shafiee Abbas,
Foroumadi Alireza
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2144
Subject(s) - chemistry , dabco , amide , alkylation , propargyl bromide , propargyl , organic chemistry , ethanol , thiazole , combinatorial chemistry , halide , octane , catalysis
In this work, an efficient and versatile synthesis of novel thiazol‐2‐ylidene‐amides from various carbonylthiourea derivatives is described. A sequential alkylation–cyclization reaction between thioureas and propargyl bromide in the presence of DABCO in refluxing ethanol afforded 4‐methylthiazol‐2(3 H )‐ylidene‐amide derivatives in good yields.