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An Efficient Synthesis of Polyfunctionalized Indole Derivatives via Three‐component Domino Reaction Catalyzed by L ‐Proline
Author(s) -
Fu Lei,
Lin Wei,
Huang ZhiBin,
Shi DaQing
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2133
Subject(s) - chemistry , malononitrile , ninhydrin , indole test , catalysis , domino , cascade reaction , proline , component (thermodynamics) , combinatorial chemistry , reaction conditions , organic chemistry , amino acid , biochemistry , physics , thermodynamics
A facile and efficient one‐pot procedure for the preparation of indeno[1,2‐ b ]indole derivatives via three‐component domino reaction of ninhydrin, enaminones, and malononitrile catalyzed by L ‐proline is described. In this reaction, two rings and four bonds were formed by one‐pot.