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An Efficient, Multicomponent, One‐pot Synthesis of Tetra Substituted Pyrans in Water
Author(s) -
Pagadala R.,
Maddila S.,
Jonnalagadda S. B.
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2125
Subject(s) - chemistry , malononitrile , tetra , aldehyde , pyran , diketone , solvent , organic chemistry , medicinal chemistry , catalysis
A new and environmentally benign multi‐component synthesis of tetra substituted 4 H ‐pyran derivatives is developed via the one‐pot reaction of an aromatic aldehyde, malononitrile, and 1,3‐diketone in the presence of NaOH with water as the solvent at RT. The reaction is efficient and affords excellent yields of the products.