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Sodium Formate‐Catalyzed One‐Pot Synthesis of Benzopyranopyrimidines and 4‐Thio‐substituted 4 H ‐Chromenes via Multicomponent Reaction at Room Temperature
Author(s) -
Brahmachari Goutam,
Das Suvankar
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2123
Subject(s) - chemistry , malononitrile , thio , thiophenol , catalysis , sodium formate , nucleophile , combinatorial chemistry , sn2 reaction , organic chemistry , one pot synthesis , medicinal chemistry
Abstract A simple, straightforward and highly efficient multicomponent one‐pot synthesis of a series of pharmaceutically interesting benzopyranopyrimidine and 4 H ‐chromene derivatives has been developed on the basis of low‐cost and environment‐friendly sodium formate catalyst via tandem reactions of salicylic aldehydes, malononitrile, and cyclic secondary amines in ethanol at room temperature. Nature of nucleophile used in this reaction directs the course of the reaction; cyclic secondary amines result in the formation of benzopyrano[2,3‐ d ]pyrimidines, whereas thiophenol furnish corresponding 4‐thio‐subtituted 4 H ‐chromenes under the same reaction conditions. High atom‐economy, good yields, eco‐friendly, and mild reaction conditions are some of the important features of this protocol.