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Microwave‐Assisted Direct Amidation of Ethyl 1‐Phenyl‐5‐hydroxy‐1 H ‐pyrazole‐4‐carboxylate
Author(s) -
Milošević Mladena,
Šterbal Ines,
Feguš Urban,
Baškovč Jernej,
Prek Benjamin,
Grošelj Uroš,
Stanovnik Branko,
Svete Jurij
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2100
Subject(s) - chemistry , piperidine , pyrazole , pyrrolidine , carboxylate , primary (astronomy) , organic chemistry , medicinal chemistry , microwave , physics , quantum mechanics , astronomy
Microwave‐assisted treatment of ethyl 5‐hydroxy‐1‐phenyl‐1 H ‐pyrazole‐4‐carboxylate with excess primary aliphatic amines in 1‐propanol at 140°C and with excess pyrrolidine or piperidine in 2‐methoxyethanol at 180°C produced the corresponding carboxamides in good yields.