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Synthesis and biological activities of O‐(E) ‐(arylmethyl) 1‐[1‐(arylmethyl)‐5‐methyl‐1 H ‐1,2,3‐triazol‐4‐yl] ethanone oxime ethers
Author(s) -
Zhu XiaoFei,
Shi DeQing
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.209
Subject(s) - chemistry , oxime , rhizoctonia solani , alkylation , medicinal chemistry , proton nmr , organic chemistry , nuclear chemistry , stereochemistry , catalysis , botany , biology
A series of novel O ‐( E )‐(arylmethyl) 1‐[1‐(arylmethyl)‐5‐methyl‐1 H ‐1,2,3‐triazol‐4‐yl] ethanone oxime ethers were synthesized by the O ‐alkylation of 1‐[1‐(arylmethyl)‐5‐methyl‐1 H ‐1,2,3‐triazol‐4‐yl] ethanone oximes with various arylmethyl chlorides in the basic condition. Their structures were confirmed by IR, 1 H NMR, mass spectroscopy, and elemental analyses. The preliminary bioassay indicated that some of the target compounds ( 4a , 4b , 4c , 4d , 4e , 4f ) displayed good insecticidal and moderate fungicidal activity. For example, compounds 4c and 4g showed 100% and 90.6% death rates against aphides at the concentration of 250 mg/L, respectively, and compounds 4f and 4g displayed 67% and 78.4% inhibitory rates against Rhizoctonia solani at the dosage of 100 mg/L, respectively. J. Heterocyclic Chem., (2009).