Synthesis and biological activities of O‐(E) ‐(arylmethyl) 1‐[1‐(arylmethyl)‐5‐methyl‐1 H ‐1,2,3‐triazol‐4‐yl] ethanone oxime ethers

A series of novel O ‐( E )‐(arylmethyl) 1‐[1‐(arylmethyl)‐5‐methyl‐1 H ‐1,2,3‐triazol‐4‐yl] ethanone oxime ethers were synthesized by the O ‐alkylation of 1‐[1‐(arylmethyl)‐5‐methyl‐1 H ‐1,2,3‐triazol‐4‐yl] ethanone oximes with various arylmethyl chlorides in the basic condition. Their structures were confirmed by IR, 1 H NMR, mass spectroscopy, and elemental analyses. The preliminary bioassay indicated that some of the target compounds ( 4a , 4b , 4c , 4d , 4e , 4f ) displayed good insecticidal and moderate fungicidal activity. For example, compounds 4c and 4g showed 100% and 90.6% death rates against aphides at the concentration of 250 mg/L, respectively, and compounds 4f and 4g displayed 67% and 78.4% inhibitory rates against Rhizoctonia solani at the dosage of 100 mg/L, respectively. J. Heterocyclic Chem., (2009).