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[1,3]Thiazolo[2′,3′:3,4][1,2,4]triazolo[1,5‐ a ]pyrimidines – A New Heterocyclic System Accessed via Bromocyclization
Author(s) -
Fizer Maksym,
Slivka Mikhailo,
Rusanov Eduard,
Turov Alexandr,
Lendel Vasil
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2073
Subject(s) - chemistry , halogenation , bromine , acetic acid , pyrimidine , allylamine , yield (engineering) , electrophile , medicinal chemistry , combinatorial chemistry , sodium azide , organic chemistry , stereochemistry , catalysis , polyelectrolyte , metallurgy , polymer , materials science
A facile access to novel condensed system of [1,3]thiazolo[2′,3′:3,4][1,2,4]triazolo[1,5‐a]pyrimidine is presented. This protocol consists of bromine‐assisted direct electrophilic heterocyclization of 3‐ N ‐allylamine‐5,6‐dihydro[1,3]thiazolo[2,3‐ c ][1,2,4]triazole. The bromination took place in acetic acid and gave a good yield of the target product, which was dehydrobrominated by sodium acetate action.