[1,3]Thiazolo[2′,3′:3,4][1,2,4]triazolo[1,5‐ a ]pyrimidines – A New Heterocyclic System Accessed via Bromocyclization | Zendy

Fizer Maksym | Zendy; Slivka Mikhailo | Zendy; Rusanov Eduard | Zendy; Turov Alexandr | Zendy; Lendel Vasil | Zendy

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[1,3]Thiazolo[2′,3′:3,4][1,2,4]triazolo[1,5‐ a ]pyrimidines – A New Heterocyclic System Accessed via Bromocyclization

Author(s) -

Fizer Maksym,

Slivka Mikhailo,

Rusanov Eduard,

Turov Alexandr,

Lendel Vasil

Publication year - 2015

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2073

Subject(s) - chemistry , halogenation , bromine , acetic acid , pyrimidine , allylamine , yield (engineering) , electrophile , medicinal chemistry , combinatorial chemistry , sodium azide , organic chemistry , stereochemistry , catalysis , polyelectrolyte , metallurgy , polymer , materials science

A facile access to novel condensed system of [1,3]thiazolo[2′,3′:3,4][1,2,4]triazolo[1,5‐a]pyrimidine is presented. This protocol consists of bromine‐assisted direct electrophilic heterocyclization of 3‐ N ‐allylamine‐5,6‐dihydro[1,3]thiazolo[2,3‐ c ][1,2,4]triazole. The bromination took place in acetic acid and gave a good yield of the target product, which was dehydrobrominated by sodium acetate action.

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