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Synthesis and Reactivity of 2‐Pyrrolidino‐, 2‐ N ‐Methylpiperazino‐, 2‐Piperidino‐, and 2‐Morpholino‐1,3,4‐thiadiazines
Author(s) -
Knak Stefanie,
Pfeiffer WolfDiethard,
Dollinger Horst,
Langer Peter
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2072
Subject(s) - chemistry , morpholino , medicinal chemistry , phenacyl , halide , flue gas desulfurization , reactivity (psychology) , combinatorial chemistry , organic chemistry , biochemistry , zebrafish , gene , medicine , alternative medicine , pathology
A variety of 2‐pyrrolidino‐, 2‐ N ‐methylpiperazino‐, 2‐piperidino‐, and 2‐morpholino‐1,3,4‐thiadiazines were prepared by cyclocondensation of phenacyl halides with thiosemicarbazides. Heating of the products resulted in desulfurization and formation of pyrazoles. The rate of this process strongly depends on the substitution pattern of the 1,3,4‐thiadiazines.