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Feasible Approach to Tricyclic and Tetracyclic cyclododecanone
Author(s) -
Zoorob Hanafi H.,
Elsherbini Mohamed S.,
Hamama Wafaa S.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2062
Subject(s) - chemistry , thiophenol , thiazole , benzimidazole , tricyclic , ring (chemistry) , stereochemistry , derivative (finance) , furan , thiol , organic chemistry , combinatorial chemistry , financial economics , economics
2‐Bromocyclododecanone was utilized as precursor to synthesize polyfused heterocyclic cyclododecane ring systems. Transformation of 2‐bromocyclododecanone ( 5 ) with 1 H ‐benzimidazole‐2‐thiole ( 6 ), benzo[ d ]thiazole‐2‐thiol ( 9 ), 2 ‐naphthol ( 12 ), and thiophenol ( 15 ) afforded thiazolo[2,3‐b]benzimidazole ( 8 ), thiazolo[2,3‐b]benzothaizole derivative ( 11 ) naphtho[1,2‐d]furan derivative ( 14 ) and 2‐(phenylthio)cyclododecanone ( 16 ), respectively.