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A Complementary Synthetic Approach to Fluorazone
Author(s) -
Calvert Matthew B.,
Sperry Jonathan
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2060
Subject(s) - chemistry , regioselectivity , acylation , microwave irradiation , pyrrole , zinc , chloride , combinatorial chemistry , catalysis , organic chemistry , medicinal chemistry
Pyrrole undergoes a regioselective zinc‐mediated acylation with 2‐bromobenzoyl chloride followed by a Cu‐catalyzed N‐arylation under microwave irradiation , delivering the important heteroaromatic of fluorazone.