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Synthesis, Antimicrobial, and Brine Shrimps Lethality Assays of 3,3‐Diaryl‐4‐(1‐methyl‐1 H ‐indol‐3‐yl)azetidin‐2‐ones
Author(s) -
Singh Girija S.,
Alkahraman Yasser M. S. A.,
Mpadi Disah,
Yasinzai Masoom
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2057
Subject(s) - chemistry , lethality , antimicrobial , brine , antifungal , diazo , brine shrimp , antibacterial activity , biological activity , combinatorial chemistry , carbon 13 nmr , elemental analysis , bacteria , organic chemistry , stereochemistry , microbiology and biotechnology , traditional medicine , biochemistry , in vitro , toxicology , medicine , genetics , biology
The paper describes the synthesis, characterization data, and biological activity (antibacterial, antifungal, and brine shrimps lethality) of new azetidin‐2‐ones. The compounds have been synthesized by the reaction of diarylketenes, generated in situ from thermal decomposition of the 2‐diazo‐1,2‐diarylethanones, with N ‐(1‐methyl‐1 H ‐indol‐3‐yl)methyleneamines. The compounds have been characterized by elemental analysis and spectral (IR, 1 H and 13 C NMR, and MS) data. The paper also reports the results of antibacterial, antifungal, and brine shrimps lethality assays of these compounds. Some of the compounds exhibited significant biological activity .