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Copper‐catalyzed Cyclization of 3‐Acylcoumarin Hydrazone using Air as the Oxidant: Efficient Synthesis of Pyrazole‐Fused Coumarin Derivatives
Author(s) -
Wang HuiYan,
Liu XueCheng,
Huang ZhiBin,
Shi DaQing
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2052
Subject(s) - chemistry , hydrazone , pyrazole , coumarin , catalysis , copper , combinatorial chemistry , oxidation process , oxidative phosphorylation , organic chemistry , medicinal chemistry , chemical engineering , biochemistry , engineering
An efficient, convenient Cu‐catalyzed formation of chromeno[4,3‐ c ]pyrazol‐4(1 H )‐ones is reported. In this atom economic process, readily available 3‐acylcoumarin hydrazone is oxidative cyclized by direct C–N bond formation. Air has been successfully used as an oxidant, which has important economic and environmental advantages. A broad scope of 3‐acylcoumarin hydrazones can be utilized in this process.