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Synthesis and In Vitro Antimicrobial Activity of 1,3,4‐Oxadiazole‐2‐thiol and its Analogs
Author(s) -
Galge R.,
Raju A.,
Degani M. S.,
Thorat B. N.
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2042
Subject(s) - chemistry , morpholine , antimicrobial , bacillus subtilis , candida albicans , oxadiazole , thiol , bacteria , escherichia coli , ciprofloxacin , antifungal , antibacterial activity , stereochemistry , fluconazole , proton nmr , in vitro , combinatorial chemistry , organic chemistry , microbiology and biotechnology , biochemistry , antibiotics , genetics , gene , biology
The present communication deals with the synthesis of 1,3,4‐oxadiazole‐2‐thiol derivatives containing cyclic secondary amines such as morpholine, N ‐methyl piperizine, and piperizine. The structural elucidation is based on the spectral data (IR, 1 H NMR, and 13 C NMR) .The newly synthesized compounds were then tested for their antimicrobial activity against a representative panel of micro‐organisms such as Bacillus subtilis , Escherichia coli and Candida albicans by using ciprofloxacin and fluconazole as reference drugs for bacteria and fungi, respectively. These synthesized compounds showed moderate to potential antibacterial and antifungal activity in the range of 6–50 μM against the selected bacteria and 12–50 μM against the most common fungi, respectively.