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Synthesis and Biological Activity Studies of Some Novel Mannich Bases of Benzotriazolyl Triazoles
Author(s) -
George Sonia,
Chakraborty Raja,
Parameswaran Manojkumar,
Rajan Anju,
Ravi Thengungal Kochupaappy
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2029
Subject(s) - chemistry , piperazine , ammonium acetate , antimicrobial , mannich reaction , ammonium , elemental analysis , aryl , organic chemistry , proton nmr , medicinal chemistry , combinatorial chemistry , catalysis , alkyl , high performance liquid chromatography
A series of substituted phenyl methyl piperazine triazolyl benzotriazoles 4a , 4b , 4c , 4d , 4e , 4f , 4g have been synthesized through the Mannich reaction of substituted phenyl triazolyl benzotriazoles 3a , 3b , 3c , 3d , 3e , 3f , 3g . The substituted phenyl triazolyl benzotriazoles were prepared from benzotriazolyl acetohydrazide, where the cyclization was facilitated through ammonium acetate and aryl aldehydes. The IR, 1 H NMR, mass spectral data and elemental analysis were performed to assign the structure. All the newly synthesized compounds were screened for their antimicrobial and antioxidant activity.