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Synthesis, reactivity, and NMR spectroscopy of 4,6‐ and 6,7‐difluoro‐3‐methyl‐1 H ‐indazoles
Author(s) -
Medina Carlos Pérez,
López Concepción,
Claramunt Rosa M.,
Elguero José
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.202
Subject(s) - chemistry , nitration , reactivity (psychology) , fluorine 19 nmr , nuclear magnetic resonance spectroscopy , solid state , solid state nuclear magnetic resonance , fluorine , spectroscopy , medicinal chemistry , stereochemistry , organic chemistry , nuclear magnetic resonance , medicine , alternative medicine , pathology , physics , quantum mechanics
AbstractFour 1 H ‐indazoles, two of them doubly substituted by fluorine atoms and the other two obtained by nitration of the foregoing derivatives, were prepared and fully characterized by multinuclear NMR in solution and in solid state in view of their potential nitric oxide synthase inhibition properties. J. Heterocyclic Chem., (2009).