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Synthesis, Characterization, and Antibacterial Activity of Novel (1H‐Benzo[d]imidazole‐2‐yl)‐6‐(diethylamino)‐3H‐one‐xanthene, Phenoxazine, and Oxazine
Author(s) -
Patil Vikas S.,
Padalkar Vikas S.,
Phatangare Kiran R.,
Umape Prashant G.,
Borase Bhushan N.,
Sekar N.
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1998
Subject(s) - chemistry , phenoxazine , xanthene , benzimidazole , antibacterial activity , fluorescence , imidazole , bacillus subtilis , micrococcus luteus , combinatorial chemistry , nuclear chemistry , organic chemistry , escherichia coli , phenothiazine , bacteria , biochemistry , medicine , physics , pharmacology , genetics , quantum mechanics , biology , gene
A series of novel (1H‐benzo[d]imidazole‐2‐yl)‐6‐(diethylamino)‐3H‐one‐xanthene, phenoxazine, and oxazine derivatives have been synthesized from 2‐(2′,4′‐dihydroxyphenyl) benzimidazole intermediate . Synthesized compounds 8a , 8b , 8c , 8d are fluorescent in solution, photophysical properties of compounds were studied and results revealed that compounds absorb and emit in UV–visible region with good fluorescence quantum yield. Synthesized compounds are thermally stable up to 300°C. The antibacterial activities of the synthesized compounds were studied by the well‐diffusion method. Escherichia coli (ATTC‐25922), Staphylococcus aureus (ATCC‐25923), Micrococcu s (ATCC‐4698), and Bacillus subtilis (ATCC‐55422) were used to investigate the antibacterial activities.