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Microwave‐Assisted Aqueous Reactions: An Efficient Route to Benzodiazepines
Author(s) -
Zhu XiaoTong,
Liu JiaYan,
Jiang Bo,
Tu ShuJiang
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1988
Subject(s) - chemistry , microwave irradiation , aqueous solution , microwave , combinatorial chemistry , reaction conditions , organic chemistry , green chemistry , catalysis , reaction mechanism , physics , quantum mechanics
Microwave‐assisted three‐ component reaction has been established for the synthesis of benzodiazepines. This reaction promoted by HOAc was conducted by using readily available and inexpensive starting materials in water under microwave irradiation . The present green synthesis shows fascinating characteristics such as the use of water as the reaction solution, concise one‐pot conditions, short reaction periods, easy purification, and reduced waste production without the use of any strong acids or metal promoters.