Premium
Thermal Synthesis of 3‐Bromothieno[3,2‐ c ]pyridin‐4‐(5 H )‐one: A Telescoped Procedure with Tributylamine
Author(s) -
Boros Eric E.,
Kaldor Istvan
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1981
Subject(s) - chemistry , isomerization , isocyanate , thermal , pyridine , organic chemistry , medicinal chemistry , polymer chemistry , polyurethane , catalysis , thermodynamics , physics
3‐Bromothieno[3,2‐ c ]pyridine‐4‐(5 H )‐one ( 1 ) was prepared from (2 E )‐3‐(4‐bromo‐2‐thienyl)‐2‐propenoic acid ( 3 ) by the Eloy–Deryckere thermal benzo/heteropyridinone synthesis. A telescoped procedure was developed, which reduces some of the risk associated with the classic procedure. Use of tributylamine as an additive in this process was shown to facilitate E / Z ‐isomerization of the intermediate vinyl isocyanate and lower the temperature necessary for the overall thermal process.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom