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Synthesis and Pharmacological Evaluation of 3‐propyl‐2‐substitutedamino‐3 H ‐quinazolin‐4‐ones as Analgesic and Anti‐Inflammatory Agents
Author(s) -
Sheorey R. V.,
Thangathiruppathy A.,
Alagarsamy V.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1973
Subject(s) - chemistry , diclofenac sodium , analgesic , analgesic agents , propylamine , quinazoline , diclofenac , stereochemistry , pharmacology , medicinal chemistry , organic chemistry , amine gas treating , biochemistry , chromatography , medicine
A variety of novel 3‐propyl‐2‐substitutedamino‐quinazolin‐4(3 H )‐ones were synthesized by reacting the amino group of 2‐hydrazino‐3‐propyl quinazolin‐4(3 H )‐one with a variety of aldehydes and ketones. The starting material 2‐hydrazino‐3‐propyl quinazolin‐4(3 H )‐one was synthesized from propylamine. The title compounds were investigated for analgesic and anti‐inflammatory activities. The compound 2‐(1‐ethylpropylidene‐hydrazino)‐3‐propyl‐quinazolin‐4(3 H )‐one ( SR2 ) emerged as the most active compound of the series, and it is more potent in its analgesic and anti‐inflammatory activities when compared with the reference standard diclofenac sodium.