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Microwave‐Assisted Synthesis of Pyrrolo[2,1‐ b ]thiazoles Linked to a Carbohydrate Moiety
Author(s) -
Barradas José Sebastián,
Errea María Inés,
Sepúlveda Claudia,
Damonte Elsa Beatriz,
D'Accorso Norma Beatriz
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1957
Subject(s) - chemistry , moiety , thiazole , carbohydrate , bicyclic molecule , microwave irradiation , alkylation , stereochemistry , cytotoxicity , combinatorial chemistry , organic chemistry , biochemistry , in vitro , catalysis
Herein, we describe the synthesis of pyrrolo[2,1‐ b ]thiazoles substituted on C‐2 or C‐5 with a protected carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and the N‐alkylation step was assisted by microwave irradiation . The new products were completely characterized by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus of the methylated derivates was also evaluated.