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Highly Efficient Cycloaddition Reaction of 1,3‐Diynes with Sodium Azide: A New Way to 5‐Substituted‐4‐acetylene‐1 H ‐1,2,3‐triazoles
Author(s) -
Tang JiaLiang,
Ming Ling,
Zhao XiaoMing
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1950
Subject(s) - chemistry , acetylene , cycloaddition , sodium azide , azide , sodium , organic chemistry , medicinal chemistry , combinatorial chemistry , catalysis
A cycloaddition reaction of a range of 1,3‐diynes with sodium azide has been realized, which provided 5‐substituted‐4‐acetylene‐1 H ‐1,2,3‐triazoles in 75–99% yields. The chemical structures of the new compounds 3 are established by IR, NMR, Mass, and HRMS.