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Synthesis and Biological Activity of 1‐(Substituted phenoxyacetoxy)‐1‐(pyridin‐2‐yl or thien‐2‐yl)methylphosphonates
Author(s) -
Wang Tao,
Wang Wei,
Peng Hao,
He Hongwu
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1944
Subject(s) - sclerotinia sclerotiorum , chemistry , gibberella zeae , fusarium oxysporum , bioassay , botrytis cinerea , hydrazide , fusarium , stereochemistry , organic chemistry , botany , biology , genetics
A series of novel O , O ‐dimethyl 1‐(substituted phenoxyacetoxy)‐1‐(pyridin‐2‐yl or thien‐2‐yl)methylphosphonates 6a , 6b , 6c , 6d , 6e , 6f , 6g , 6h , 6i , 6j , 6k , 6l , 6m , 6n and 7a , 7b , 7c , 7d were synthesized. Their structures were confirmed by IR, 1 H NMR, mass spectroscopy, and elemental analyses. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal and fungicidal activities. For example, the title compounds 6a , 6c , 6l , 6m , and 7d possess 90–100% inhibition against most of the tested plants at the dosage of 1500 g ai/ha, whereas the title compounds 6b , 6g , 6h and 6n possess 92–100% inhibition against Fusarium oxysporum , Phyricularia grisea , Botrytis cinereapers , Gibberella zeae , Sclerotinia sclerotiorum , and Cercospora beticola at the concentration of 50 mg/L.