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Novel Synthesis of Some Imidazolyl‐, Benzoxazinyl‐, and Quinazolinyl‐2,4‐dioxothiazolidine Derivatives
Author(s) -
Youssef Ali M.,
ELZiaty Ahmed K.,
AbouElmagd Wael S. I.,
Ramadan Sayed K.
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1943
Subject(s) - chemistry , anthranilic acid , aspergillus flavus , antimicrobial , candida albicans , acetic acid , bacteria , escherichia coli , staphylococcus aureus , antibacterial activity , organic chemistry , microbiology and biotechnology , biochemistry , genetics , food science , gene , biology
2‐(2,4‐Dioxothiazolidin‐5‐yl)acetic acid 1 and its chloride derivative 2 were allowed to react with different aromatic amines such as o ‐phenylenediamine, o ‐aminothiophenol, p ‐aminoacetophenone, and anthranilic acid to give the biologically active nuclei such as imidazoles, thiazoles, benzoxazines, and quinazolines incorporated with the thiazolidindione nucleus. The antimicrobial activity of five of the synthesized compounds was examined against one gram positive bacteria ( Staphylococcus aureus ), one gram negative bacteria ( Escherichia coli ), and two fungi ( Aspergillus flavus and Candida albicans ). Four compounds showed moderate antibacterial and antifungal activities.