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New Method for the Synthesis and Reactivity of (5‐R‐1,3,4‐Oxadiazol‐2‐yl)furoxans
Author(s) -
Fershtat Leonid L.,
Kulikov Alexander S.,
Ananyev Ivan V.,
Struchkova Marina I.,
Makhova Ni.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1940
Subject(s) - chemistry , furoxan , furan , hydrazide , reactivity (psychology) , pyrrole , oxadiazole , thiophene , organic chemistry , triazole , pyrimidine , combinatorial chemistry , stereochemistry , nitric oxide , medicine , alternative medicine , pathology
A new, simple and general one‐pot method for the preparation of (5‐R‐1,3,4‐oxadiazol‐2‐yl)furoxans has been developed on the basis of the interaction between accessible 3‐methylfuroxan‐4‐carboxylic acid hydrazide and aliphatic, aromatic and heterocyclic carboxylic acids or their chlorides in the presence of POCl 3 . The synthesis and study of (5‐R‐1,3,4‐oxadiazol‐2‐yl)furoxans reactivity resulted in new polyheterocyclic ensembles incorporating furoxan, 1,3,4‐oxadiazole, pyrrole, triazole, furan, thiophene, pyrimidine, and other heterocycles in different combinations.