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Two‐Step Synthesis of Multifunctional γ‐Lactams from γ‐Lactone
Author(s) -
Béji Feten,
Taktouk Sonia,
Kraïem Jihène Ben,
AlDeyab Salem S.,
Amri Hassen
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1932
Subject(s) - chemistry , conjugate , lactone , intramolecular force , lactam , combinatorial chemistry , acrylate , stereochemistry , organic chemistry , copolymer , polymer , mathematical analysis , mathematics
We present herein an efficient and rapid method for the synthesis of N ,1‐dialkyl‐4‐(2‐hydroxyethyl)‐5‐oxopyrrolidine‐3‐carboxamides based on the conversion of γ‐lactone to γ‐lactam via the conjugate addition of primary amines to an ethyl α‐functionalized acrylate followed by intramolecular cyclization .