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Study of the Reactivity of 6,8‐Dimethyl‐4‐oxo‐4 H ‐1‐benzopyran‐3‐carboxaldehyde Towards Amino‐6‐oxopyridine‐3‐carboxylate Derivatives
Author(s) -
ElShaaer Hafez Mohamed,
AbdElmonem Wafaa Ramzy,
Ibrahim Salah Sayed,
Ibrahim Christine Gamal
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1919
Subject(s) - chemistry , carboxylate , medicinal chemistry , benzene , reactivity (psychology) , acetic anhydride , ethanol , solvent , organic chemistry , xylene , condensation , acetic acid , benzopyran , catalysis , medicine , alternative medicine , physics , pathology , thermodynamics
The condensation reactions of 6,8‐dimethyl‐4‐oxo‐4 H ‐1‐benzopyran‐3‐carboxaldehyde ( 1 ) with equimolar amounts of ethyl 2‐amino‐4‐(4‐chlorophenyl)‐5‐cyano‐1‐[(5,6‐diphenyl‐1,2,4‐triazin‐3‐yl)amino]‐6‐oxo‐1,6‐dihydropyridine‐3‐carboxylate ( 2 ) at different reaction conditions gave different chromanone and chromenone products 3 , 4 , 5 . Also, the condensation reactions of compound 1 with ethyl 5‐cyano‐1,2‐diamino‐4‐(3‐nitrophenyl)‐6‐oxo‐1,6‐dihydropyridine‐3‐carboxylate ( 6 ) in absolute ethanol, dry benzene, acetic acid , and/or dry xylene gave a variety of products 7 , 8 , 9 , 10 depending on the solvent used.