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Reactions of Nucleophilic Substitution in Bicyclic Nitroimidazodihydrooxazoles
Author(s) -
Żwawiak Justyna,
Zaprutko Lucjusz
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1907
Subject(s) - chemistry , nucleophile , reactivity (psychology) , bicyclic molecule , chlorine atom , ring (chemistry) , nucleophilic substitution , solvent , substitution reaction , chlorine , medicinal chemistry , phenols , nucleophilic aromatic substitution , solvent polarity , organic chemistry , combinatorial chemistry , catalysis , medicine , alternative medicine , pathology
This article describes numerous attempts of the S N reaction of chlorine atom in chloromethyl group with nucleophilic compounds, such as the following: phenols, thiophenols, and amino compounds. The influences of ratios of nitroimidazodihydrooxazoles, nucleophiles and basic agent, and the polarity of solvent on the kind of formed products were established. Also, the comparison of reactivity with nucleophiles of close structural isomers of nitroimidazodihydrooxazoles has been made. The way of formation ring opening reaction products has been proposed.