One‐Pot Synthesis  of 2‐Oxazolines from Ethyl  α ‐Cyanocinnamate Derivatives with  N ‐Bromoacetamide | Zendy

Chen Zhanguo | Zendy; Wen Hua | Zendy; Li Wenli | Zendy; Zhou Jimei | Zendy; Hu Junli | Zendy; Xia Wei | Zendy

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One‐Pot Synthesis of 2‐Oxazolines from Ethyl α ‐Cyanocinnamate Derivatives with N ‐Bromoacetamide

Author(s) -

Chen Zhanguo,

Wen Hua,

Li Wenli,

Zhou Jimei,

Hu Junli,

Xia Wei

Publication year - 2014

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.1902

Subject(s) - chemistry , nucleophile , acetone , nucleophilic addition , organic chemistry , inert , reaction conditions , medicinal chemistry , combinatorial chemistry , catalysis

An efficient method for the one‐pot synthesis of 2‐oxazolines from ethyl α‐cyanocinnamate derivatives with N ‐bromoacetamide in the presence of K 3 PO 4 has been developed. The reaction performed smoothly and cleanly to give 2‐oxazolines in good to excellent yields (up to 98%) within 4.5 h in acetone at room temperature without protection of inert gases. A total of 13 examples have been investigated. A possible nucleophilic addition reaction mechanism is proposed.

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