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Mercury(II) Chloride‐Mediated Desulphurization of Amidinothioureas: Synthesis and Antimicrobial Activity of 3‐Amino‐1,2,4‐triazole Derivatives
Author(s) -
Yerande Swapnil G.,
Baviskar Chetna D.,
Newase Kiran M.,
Wang Wei,
Wang Kan,
Dömling Alexander
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1890
Subject(s) - chemistry , mercury (programming language) , antimicrobial , chloride , annulation , combinatorial chemistry , 1,2,4 triazole , triazole , organic chemistry , catalysis , programming language , computer science
The synthesis of 3-amino-1,2,4-triazole via mercury(II) chloride-mediated cyclization of amidinothiourea is described. This procedure offers a general and efficient route to synthesize the title compound by 3 + 2 annulation reaction. On the basis of the literature precedence, the mechanism for the formation of 3-amino-1,2,4-triazole is proposed. When the synthesized compounds were tested for their antimicrobial activity showed promising inhibition against tested microbes

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