Premium
Synthesis of 6‐Fluoro‐7‐cyclic Amino‐substituted Dicarboxylic Acid Quinolones and their Antibacterial Activity
Author(s) -
Ravi Kumar A.,
Sathaiah G.,
Chandra Shekhar A.,
Raju K.,
Shanthan Rao P.,
Narsaiah B.,
Kanaka Raju Y.,
Murthy U. S. N.,
Srimai V.,
Ramesh M.,
Parthasarathy T.
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1889
Subject(s) - chemistry , quinoline , antibacterial activity , ethyl bromoacetate , carboxylic acid , docking (animal) , gram , stereochemistry , combinatorial chemistry , organic chemistry , bacteria , medicine , genetics , nursing , biology
Novel 1‐carboxymethyl‐6‐fluoro‐7‐cyclic amino‐substituted‐4‐oxo‐1,4‐dihydroquinolone‐3‐carboxylic acids 7a , 7b , 7c , 7d , 7e , 7f , 7g , 7h , 7i , 7j , 7k , 7l , 7m , 7n were synthesized as a new class of quinolones. Ethyl‐6‐fluoro‐7‐chloro‐1,4‐dihydro‐4‐quinoline‐3‐carboxylic acid was prepared from conventional method and reacted with ethyl bromoacetate to furnish N ‐carboxymethyl derivatives. The compounds were screed against various Gram‐positive and Gram‐negative bacterial strains. Antibacterial activity data is validated by molecular docking studies.