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Guanidine Hydrochloride: A Highly Efficient Organocatalyst for the Synthesis of 12‐Aryl‐8,9,10,12‐tetrahydrobenzo[ a ]xanthene‐11‐ones Under Solvent‐Free Conditions
Author(s) -
Sadeghpour Mahdieh,
Olyaei Abolfazl,
Rezaei Mortaza
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1879
Subject(s) - chemistry , guanidine , xanthene , hydrochloride , solvent , aryl , organic chemistry , combinatorial chemistry , reaction conditions , catalysis , alkyl
A new green protocol has been developed for the synthesis of 12‐aryl‐8,9,10,12‐tetrahydrobenzo[ a ]xanthen‐11‐ones using guanidine hydrochloride as an organocatalyst under solvent‐free conditions. Operational simplicity, mild reaction conditions, enhanced rates, high isolated yields of the pure products, and purification of products by nonchromatographic methods are significant advantages of the protocol presented here.