Premium
A facile and efficient synthesis of N ‐substituted furo[3,4‐ b ]indeno[2,1‐ e ]pyridine analogues of azapodophyllotoxin via microwave‐assisted multicomponent reactions
Author(s) -
Shi Feng,
Zhang Ge,
Zhang Yan,
Ma Ning,
Jiang Bo,
Tu ShuJiang
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.187
Subject(s) - chemistry , pyridine , yield (engineering) , indene , aldehyde , furan , catalysis , microwave , combinatorial chemistry , simplicity , microwave irradiation , organic chemistry , philosophy , materials science , physics , epistemology , quantum mechanics , metallurgy
The efficient and facile synthesis of N ‐substituted furo[3,4‐ b ]indeno[2,1‐ e ]pyridine analogues of azapodophyllotoxin was achieved via microwave‐assisted multicomponent reactions of aldehyde, 2 H ‐indene‐1,3‐dione and 4‐(arylamino)furan‐2(5 H )‐one in glycol without catalyst. This method has the obvious advantages over traditional heating ones on short reaction time, high yield, operational simplicity as well as being environmental friendly. J. Heterocyclic Chem., (2009).