One‐Pot Synthesis  of New 1,5‐Disubstituted Tetrazoles Bearing 2,2‐Bis(trimethylsilyl)ethenyl Groups via The Ugi Four‐Component  Condensation Reaction  Catalyzed by MgBr 2 ·2Et 2 O | Zendy

Safa Kazem D. | Zendy; Shokri Tohid | Zendy; Abbasi Hassan | Zendy; TeimuriMofrad Reza | Zendy

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One‐Pot Synthesis of New 1,5‐Disubstituted Tetrazoles Bearing 2,2‐Bis(trimethylsilyl)ethenyl Groups via The Ugi Four‐Component Condensation Reaction Catalyzed by MgBr 2 ·2Et 2 O

Author(s) -

Safa Kazem D.,

Shokri Tohid,

Abbasi Hassan,

TeimuriMofrad Reza

Publication year - 2014

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.1858

Subject(s) - chemistry , trimethylsilyl , benzaldehyde , catalysis , condensation , solvent , condensation reaction , organic chemistry , aldehyde , component (thermodynamics) , medicinal chemistry , physics , thermodynamics

A simple one‐pot Ugi four‐component condensation reaction has been developed for the synthesis of tetrazoles bearing 2,2‐bis(trimethylsilyl)ethenyl groups from the synthesized 4‐[2,2‐bis(trimethylsilyl) ethenyl]benzaldehyde ( 1 ), various amines, isocyanides, and trimethylsilylazide at room temperature, without solvent, and in the presence of catalytic amounts of MgBr 2 ·2Et 2 O as catalyst.

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