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One‐Pot Synthesis of New 1,5‐Disubstituted Tetrazoles Bearing 2,2‐Bis(trimethylsilyl)ethenyl Groups via The Ugi Four‐Component Condensation Reaction Catalyzed by MgBr 2 ·2Et 2 O
Author(s) -
Safa Kazem D.,
Shokri Tohid,
Abbasi Hassan,
TeimuriMofrad Reza
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1858
Subject(s) - chemistry , trimethylsilyl , benzaldehyde , catalysis , condensation , solvent , condensation reaction , organic chemistry , aldehyde , component (thermodynamics) , medicinal chemistry , physics , thermodynamics
A simple one‐pot Ugi four‐component condensation reaction has been developed for the synthesis of tetrazoles bearing 2,2‐bis(trimethylsilyl)ethenyl groups from the synthesized 4‐[2,2‐bis(trimethylsilyl) ethenyl]benzaldehyde ( 1 ), various amines, isocyanides, and trimethylsilylazide at room temperature, without solvent, and in the presence of catalytic amounts of MgBr 2 ·2Et 2 O as catalyst.