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Solid‐Phase Organic Synthesis of 1,4‐ N ‐Vinyl‐ and 1,4‐ N ‐Allyl‐Triazoles with the Sulfonate Linker
Author(s) -
He Aiying,
Sheng Shouri,
Huang Zhenzhong,
Liu Li,
Cai Mingzhong
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1857
Subject(s) - chemistry , reagent , sulfonate , azide , yield (engineering) , alkyne , solid phase synthesis , cleavage (geology) , organic synthesis , linker , organic chemistry , combinatorial chemistry , polymer chemistry , catalysis , peptide , biochemistry , materials science , geotechnical engineering , fracture (geology) , computer science , engineering , metallurgy , operating system , sodium
Polymer‐supported 2‐azidoethyl sulfonate and 3‐azidopropyl sulfonate reagents have been developed and applied to the solid‐phase organic synthesis of 1‐vinyl‐ and 1‐allyl‐1,2,3‐triazoles, respectively, by CuI‐mediated azide‐alkyne cycloadditions and subsequent cleavage from the polymer support through elimination reaction promoted by DBU. The advantages of this new synthetic method include simple operation and high yield of the products, as well as good stability of the reagents.