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Pd‐Mediated Multicomponent Synthesis of Highly Functionalized Pyridines and Consequential C—C Coupling Using Suzuki Reaction in One Pot: Their In Vitro Evaluation as Potential Antibacterial Agents
Author(s) -
Srinivasula Reddy L.,
Ram Reddy T.,
Gangi Reddy N. C.,
Mohan Reddy Bodireddy,
Lingappa Y.
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1855
Subject(s) - chemistry , pyridine , combinatorial chemistry , suzuki reaction , antibacterial activity , coupling reaction , molecule , functional group , in vitro , gram , one pot synthesis , organic chemistry , bacteria , catalysis , biochemistry , palladium , polymer , biology , genetics
Pd‐mediated construction of pyridine scaffold and subsequent Suzuki‐based C—C coupling reaction in one pot has been accomplished for the synthesis of 4‐biaryl substituted 2‐amino‐3‐cyanopyridines via multicomponent reaction . The present multicomponent reaction is useful in structural elaboration of pyridine framework and also helpful in design and synthesis of novel and diverse analogs of complex heterocyclic compounds other than present reported molecules. Antibacterial activities of the synthesized compounds were systematically evaluated. The correlation between functional group variation and biological activities of the compounds has been evaluated against human pathogenic gram‐positive and gram‐negative bacterial strains.