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Synthesis and Antimicrobial Activity of Some Novel [4‐(1,2,3‐thiadiazol‐4‐yl)phenoxy]methylene anchored 1,3,4‐triazoles and 1,3,4‐thiadiazoles
Author(s) -
Gadhave A. G.,
Gaikar R. B.,
Kuchekar S. R.,
Karale B. K.
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1851
Subject(s) - chemistry , antimicrobial , thiadiazoles , broth microdilution , staphylococcus aureus , aspergillus niger , escherichia coli , pseudomonas aeruginosa , minimum inhibitory concentration , methylene , candida albicans , antibacterial activity , microbiology and biotechnology , methylene blue , stereochemistry , bacteria , organic chemistry , biochemistry , biology , genetics , photocatalysis , catalysis , gene
A series of novel [4‐(1,2,3‐thiadiazol‐4‐yl)phenoxy]methylene anchored 1,3,4‐triazoles ( 8a , 8b , 8c , 8d , 8e , 8f , 8g , 8h ) and 1,3,4‐thiadiazoles ( 9a , 9b , 9c , 9d , 9e , 9f , 9g , 9h , 9i ) were synthesized from thiosemicarbazide ( 7a , 7b , 7c , 7d , 7e , 7f , 7g , 7h , 7i , 7j ). The structures of these newly synthesized compounds were confirmed on the basis of IR, 1 H‐NMR, mass spectral techniques, and elemental analysis. The in vitro antimicrobial screenings of the synthesized compounds were carried out against four bacterial pathogens, namely Staphylococcus aureus , Streptococcus pyogenes , Escherichia coli , Pseudomonas aeruginosa and three fungal pathogens Candida albicans , Aspergillus niger and Aspergillus clavatus , using broth microdilution minimum inhibitory concentration method. The compounds 7d , 7j , 8a , 9a , 9b , and 9i exhibited promising antibacterial activity against the tested strains, whereas some compounds were found to be active against one of the tested bacterial strains.