A Simple Green Protocol for the Condensation of Anthranilic Hydrazide with Cyclohexanone and  N ‐Benzylpiperidinone in Water | Zendy

Miklós Ferenc | Zendy; Fülöp Ferenc | Zendy

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A Simple Green Protocol for the Condensation of Anthranilic Hydrazide with Cyclohexanone and N ‐Benzylpiperidinone in Water

Author(s) -

Miklós Ferenc,

Fülöp Ferenc

Publication year - 2016

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.1844

Subject(s) - chemistry , cyclohexanone , hydrazide , anthranilic acid , aqueous solution , condensation , organic chemistry , catalysis , physics , thermodynamics

An environmentally benign condensation of anthranilic hydrazide with cyclohexanone or N ‐benzylpiperidin‐4‐one in aqueous medium has been developed for the synthesis of benzoylhydrazones A. The thermal rearrangements of hydrazones A yielded 3′‐aminospiro‐quinazolinones B. When A or B was reacted repeatedly with cyclohexanone or N ‐benzylpiperidin‐4‐one, spiroquinazoline‐hydrazones C were formed. From aqueous suspensions, products could be isolated in high purity by simple filtration.

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