Premium
Palladium‐catalyzed cross‐coupling reaction of 2‐ and/or 5‐substituted 4,6‐dichloropyrimidines with arylboronic acids
Author(s) -
Tumkevicius S.,
Dodonova J.,
Baskirova I.,
Voitechovicius A.
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.184
Subject(s) - chemistry , palladium , catalysis , pyrimidine , ring (chemistry) , medicinal chemistry , nitro , solvent , ligand (biochemistry) , coupling reaction , base (topology) , reaction conditions , combinatorial chemistry , organic chemistry , polymer chemistry , stereochemistry , receptor , mathematical analysis , biochemistry , alkyl , mathematics
The Suzuki‐Miyaura reaction of some 4,6‐dichloropyrimidines bearing methylthio‐, methyl‐, amino‐, cyano‐, formyl‐, and nitro groups in positions 2 and/or 5 of the pyrimidine ring with arylboronic acids has been investigated. Influence of palladium catalyst, ligand, base, and solvent on the reaction outcome was studied. The reaction was found to give the corresponding 4,6‐diarylpyrimidines in reasonable yields using Pd(OAc) 2 /PPh 3 /K 3 PO 4 or Pd(PPh 3 ) 2 Cl 2 /K 3 PO 4 as catalyst systems. J. Heterocyclic Chem., (2009).