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Novel Quinazoline Derivatives Bearing a Sulfapyridine Moiety as Anticancer and Radiosensitizing Agents
Author(s) -
Ghorab Mostafa M.,
Ragab Fatma A.,
Heiba Helmi I.,
Bayomi Ahmad A.
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1830
Subject(s) - chemistry , quinazoline , moiety , in vitro , in vivo , doxorubicin , biological activity , cell culture , combinatorial chemistry , pharmacology , stereochemistry , biochemistry , chemotherapy , medicine , genetics , microbiology and biotechnology , surgery , biology
Quinazoline derivatives posses many types of biological activities and have recently been reported to show substantial antitumor activity in vitro and/or in vivo . There is a variety of mechanisms for their anticancer activity. The present work reports the possible utility of methyl anthranilate in the synthesis of some new quinazoline derivatives, bearing a substituted sulfonamide moiety. All the newly synthesized compounds were evaluated for their in vitro anticancer activity against human liver cancer cell line, using doxorubicin as a reference drug. In addition, the most active compounds 14 and 15 were selected and evaluated for their ability to enhance the cell killing effect of γ‐radiation.