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Further Studies with Ethyl 5‐Amino‐3‐phenyl‐l H ‐pyrazole‐4‐carboxylate 1
Author(s) -
Ghozlan Said A. S.,
Abdelrazek Fathy M.,
Mohammed Mona H.,
Azmy Khaled E.
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1802
Subject(s) - chemistry , carboxylate , reagent , pyrazole , methylene , medicinal chemistry , stereochemistry , organic chemistry
The newly synthesized ethyl 3‐amino‐5‐phenylpyrazole‐4‐carboxylate 1 was diazotized and coupled with β‐naphthol, active methylene reagents 6 , 9 , 12 , 15 , and the active methine 19 to afford the pyrazolo[5,1‐ c ]triazines 5 , 8 , 11 , 14 , 17 , 18 , and the pyrazolo[5,1‐ c ]‐1,2,4‐triazoles 21 , 22 , and 23 , respectively. Structures are elucidated and mechanisms are discussed.